Formulation Development and Evaluation of Poorly Water Soluble Gliclazide Tablet Containing Aerosil 380 as Carrier

Formulation and Evaluation of Proliposomal Gel Containing Repaglinide Using Mannitol as Water Soluble Carrier

Aim: The aim of the present investigation was to design a proliposomal gel system of Repaglinide for the treatment of type 2 diabetes mellitus that is capable of delivering entrapped drug over an extended period of time. Method: Proliposomes of Repaglinide were prepared by thin film hydration technique by varying the composition mannitol, soya lecithin and cholesterol. Proliposome formulations ...

Pharmaceutical Formulation for Poorly Water Soluble Camptothecin Analogues

Formulation and Evaluation of Fast Disintegrating Tablet Containing Hydrochlorothizide

The aim of this study was to prepare Fast disintegrating tablet containing Hydrochlorothiazide by using Natural disintegrants. The tablets were prepared using micro crystalline cellulose as diluent and aspartame as sweetening agent along with Natural super disintegrant. The superdisintegrant used in this study was Isapghula mucilage and Banana powder. The tablets were evaluated for weight varia...

SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization

Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) were developed using well-defined excipients with the objective of mimicking digested SNEDDSs without the use of enzymes and in vitro lipolysis models and thereby enabling studies of the morphology and size of nanoemulsions as well as digested nanoemulsions by Cryo-TEM imaging and Dynamic Light Scattering. Four SNEDDSs (I-IV) were developed. ...

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v, constant) of selected water-soluble substances from among the hydrotropes (urea, sodium benzoate, sodium citrate, nicotinamide); water-soluble solids (PEG-...